Pseudoexfoliation glaucoma is type of open angle glaucoma that is caused by small fibrillar, proteinaceous materials.
Pseudoexfoliation is small whitish elastic dandruff like material that is associated with abnormalities in the basement membrane of epithelial cells of the eye such as ciliary epithelial cells, iris pigment epithelial cells and lens capsule epithelial cells.
It can be found in ciliary body, corneal endothelium, zonules, trabecular meshwork, and anterior vitreous but mostly can be seen in the front surface of the lens capsule and also around the pupil margin.
Pseudoexfoliation is also a systemic disease, not only an ocular disease in which this material can also be found in internal organs of the body such as lung, kidney, liver and gallbladder.
This material will flow with aqueous humor and by drained out the eye through trabecular meshwork. This material will accumulate in the trabecular meshwork and with time it will damage the trabecular cells and they will not long be efficient to drain out the aqueous, causing increase in intraocular pressure.
Risk factors of Pseudoexfoliation Glaucoma
In is more common Scandinavian countries and rare among African Americans and Eskimos.
Pseudoexfoliation syndrome is more common in females than in males.
Pseudoexfoliation syndrome is rarely seen before age 50 years, and its incidence increases steadily with age.