Tobradex Eye Drops
Tobradex Eye Drops is a combination of a topical corticosteroid and an antibiotic. The presence of each of them potentiates the effect of the other leading to combined anti-inflammatory and antimicrobial therapeutic effects.
What are the forms of Tobradex ?
It is isotonic aqueous solution in which each mL of it contains 0.1% dexamethasone and 3 mg of Tobramycin.
Each gram of it contains 0.1% dexamethasone and 3 mg of Tobramycin.
What is the composition of Tobradex ?
• Active Ingredients
Dexamethasone and Tobramycin.
• Inactive Ingredients
Suspension: Edetate disodium, hydroxyethyl cellulose, sodium chloride, sodium sulfate ,sodium hydroxide, sulfuric acid (to adjust pH), tyloxapol and water for injection.
Ointment: petrolatum base and mineral oil.
Suspension: benzalkonium chloride 0.01%
Ointment: chlorobutanol 0.5%
How Does it work ?
A powerful topical steroid that reaches high concentrations in the aqueous humor allowing it to produce a strong anti-inflammatory effect in the lids and anterior segment of the eye.
1. Reduce intra-ocular inflammation which occurs after ocular surgery, uveitis and ocular trauma.
2. Can be used after refractive surgery in order to reduce inflammation.
3. Can be used in patients with allergic conjunctivitis.
4. Can be used to reduce redness and swelling in patients with corneal infection but only under caution.
5. Can be used in patients who had chemical eye injuries but also under caution.
6. Can be used in patients with Hyphema in order to reduce the risk of rebleeding episodes.
What are the contraindications for using Tobradex Eye Drops ?
1. Patients suffering from herpetic eye infection such as herpetic keratitis but it can be used in disciform keratitis which is only caused by herpes virus.
2. Fungal Eye Infections.
3. Patients having mycobacterial infection in their eyes.
4. Acanthamoeba keratitis which occurs mainly after lasik eye surgery.
5. In patients with history of increase on intraocular pressure after the using of corticosteroid eye drops because Tobradex eye drops have corticosteroid component which is dexamethasone. This type of glaucoma is called Steroid Induced Glaucoma.
6. Patients who have allergy to Tobradex or one of its ingredients.
What are Tobradex Side Effects ?
The most common side effects of tobramycin are:
1. Hypersensitivity reaction to the product.
2. Localized toxicity resulting in itching and swelling of the eye lid and erythema of the conjunctiva.
3. Prolonged use may develop resistant microorganisms leading to persistent fungal eye infection.
While the most common side effects of steroids are:
1. Increased intra ocular pressure leading to steroid induced glaucoma.
2. Delayed healing of tissues and wounds.
3. Development of cataract especially posterior subcapsular cataract
What about Pregnant and lactating females ?
There aren’t yet studies supporting the safety of usage of Tobradex in pregnant females and it is not yet known whether Tobradex is secreted in the human breast milk or not as regarding lactating females.
Can we use Tobradex in children ?
The safety of using Tobradex in children has not been studied yet.
How should I use Tobradex Eye Drops ?
You should instill one drop in the eye to be operated on every 4 hours while the patient is awake for three days before undergoing the surgery, and every 2 hours while the patient is awake for 2 days after surgery then 4 times per day for a period of a week then 1 drop is instilled per day for 10 days.
This is the standard regimen but always you should follow your doctor instructions about the dose and frequency of it.
What are the sizes of the bottle ?
The bottle contains 2.5 mL, 5 mL and 10 mL of Tobradex sterile ophthalmic solution.